Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses
BMJ 2000; 321 doi: https://doi.org/10.1136/bmj.321.7255.199 (Published 22 July 2000) Cite this as: BMJ 2000;321:199Data supplement
Table A Comparisons of levels of risk factors and other characteristics in controls by thirds of C reactive protein concentrations. Values are mean (SD) unless stated otherwise
Top (>2.4 mg/l)
Middle (0.9-2.4 mg/l)
Bottom (<0.9 mg/l)
t value† t value‡ No of men 347 298 380 Age (years) 53.1 (5.1) 52.1 (5.3) 51.3 (5.5 4.7 2.7* No (%) current smokers 195 (56) 126 (42) 115 (30) 7.4 7.4*** No (%) >2 drinks alcohol/day 90 (26) 74 (25) 67 (18) 1.7 1.8 Physical measurements Body mass index (kg/m2) 26.2 (3.4) 25.4 (3.2) 24.3 (3.0) 7.7 9.1*** Height (cm) 172.6 (6.3) 172.8 (6.7) 173.2 (6.6) 1.3 0.6 Weight (kg) 78 (12) 76 (11) 73 (10) 6.1 7.4*** Systolic blood pressure (mmHg) 149 (20) 148 (22) 143 (20) 1.9 1.8 Diastolic blood pressure (mmHg) 83 (12) 84 (14) 81 (13) 1.9 1.3 Forced expiratory volume (l) 298 (74) 326 (75) 350 (71) 8.3 6.9*** Plasma acute phase reactants Log10 serum amyloid A protein (mg/l) 1.01 (0.32) 0.83 (0.21) 0.69 (0.26) 24 17*** Albumin (g/l) 44.0 (2.6) 44.8 (2.5) 44.8 (2.2) 5.9 3.4** Leucocyte count (×109) 7.8 (1.9) 7.2 (1.7) 6.6 (1.5) 10.7 7.6*** Other blood analytes No (%) H pylori seropositive 270 (78) 219 (73) 251 (66) 2.3 1.0 C pneumoniae titre (FC×106) 189 (58) 183 (58) 172 (62) 2.8 2.0 Total cholesterol (mmol/l) 6.29 (1.06) 6.25 (0.95) 6.07 (0.94) 2.7 1.9 HDL cholesterol (mmol/l) 1.10 (0.26) 1.18 (0.33) 1.18 (0.27) 5.0 2.6* Triglyceride (mmol/l) 2.08 (1.21) 1.93 (1.22) 1.80 (1.10) 3.1 0.9 Homocysteine (µmol/l) 15.3 (9.0) 15.4 (10.1) 14.3 (8.5) 0.7 0.7 Packed cell volume (%) 42.8 (9.9) 43.4 (6.9) 41.9 (8.5) 0.3 0.3 Glucose (mmol/l) 5.7 (1.5) 5.6 (1.5) 5.6 (1.1) 0.7 0.5 Urea (mmol/l) 5.3 (1.4) 5.5 (1.3) 5.4 (1.4) 1.7 1.3 Urate (mmol/l) 360 (69) 358 (64) 337 (65) 4.3 2.7* Creatinine (µmol/l) 99 (14) 100 (13) 98 (13) 0.3 0.8 Insulin (mU/l) 20 (20) 15 (16) 15 (14) 3.2 1.4 †Derived from regression of C reactive protein values on each characteristic separately adjusting for age and town only.
‡Derived from regression of C reactive protein values adjusting for age, town, smoking, body mass index, and markers of socioeconomic status (including height).
*P<0.01,**P<0.001,***P<0.0001.
FC=fluoresecent count.
Table B Comparisons of levels of risk factors and other characteristics in controls by thirds of serum amyloid A protein concentrations. Values are mean (SD) unless stated otherwise
Top (>9 mg/l)
Middle (6-9 mg/l)
Bottom (<6 mg/l)
t value† t value‡ No of men 362 351 312 Age (years) 52.7 (5.3) 52.1 (5.3) 51.5 (5.5) 2.9 1.6 No (%) current smokers 164 (46) 136 (39) 136 (44) 1.5 3.2* No (%) >2 drinks alcohol/day 83 (23) 79 (23) 69 (22) 1.1 0.5 Physical measurements Body mass index (kg/m2) 26.0 (3.3) 25.5 (3.1) 24.3 (3.3) 4.9 5.5*** Height (cm) 173 (6) 173 (7) 173 (7) 0.1 0.5 Weight (kg) 78 (11) 76 (10) 73 (11) 4.3 4.4*** Systolic blood pressure (mmHg) 147 (21) 148 (21) 145 (20) 0.2 0.1 Diastolic blood pressure (mmHg) 84 (14) 83 (13) 81 (13) 0.6 0.0 Forced expiratory volume (l) 314 (76) 330 (74) 335 (78) 4.0 3.4** Plasma acute phase reactants Log10 C reactive protein (mg/l) 0.47 (0.51) 0.09 (0.43) 0.14 (0.46) 24 17*** Albumin (g/l) 44.2 (2.7) 44.8 (2.3) 44.6 (2.2) 4.5 1.8 Leucocyte count (×109/l) 7.6 (1.9) 7.0 (1.6) 6.9 (1.7) 6.1 4.9*** Other blood analytes No (%) H pylori seropositive 261 (72) 258 (74) 221 (71) 0.0 0.2 C pneumoniae titre (FC×106) 185 (60) 181 (60) 176 (60) 1.1 0.1 Total cholesterol (mmol/l) 6.42 (1.08) 6.26 (0.91) 5.88 (0.89) 5.3 4.8*** HDL cholesterol (mmol/l) 1.12 (0.28) 1.14 (0.28) 1.20 (0.30) 4.1 1.5 Triglyceride (mmol/l) 1.94 (1.18) 2.00 (1.13) 1.74 (1.25) 2.2 1.2 Homocysteine (µmol/l) 15.6 (10.7) 14.3 (7.9) 15.0 (8.9) 1.0 1.2 Packed cell volume (%) 42.9 (9.2) 43.0 (7.6) 41.9 (9.0) 0.5 0.3 Glucose (mmol/l) 5.7 (1.5) 5.6 (1.0) 5.7 (1.5) 0.5 0.3 Urea (mmol/l) 5.5 (1.4) 5.4 (1.3) 5.3 (1.4) 1.4 1.5 Urate (mmol/l) 358 (70) 349 (62) 344 (68) 1.8 0.2 Creatinine (µmol/l) 100 (15) 99 (13) 98 (13) 1.2 1.7 Insulin (mU/l) 18 (20) 17 (14) 15 (17) 1.7 0.4 †Derived from regression of serum amyloid A protein C reactive protein on each characteristic separately adjusting for age and town only.
‡Derived from regression of serum amyloid A protein values adjusting for age, town, smoking, body mass index, and markers of socioeconomic status (including height).
*P<0.01,**P<0.001,***P<0.0001.
Table C Comparisons of levels of risk factors and other characteristics in controls by thirds of leucocyte count. Values are mean (SD) unless stated otherwise
Top (>7.8×109/l)
Middle (6.4-7.8×109/l)
Bottom (<6.4×109/l)
t value† t value‡ No of men 332 329 330 Age (years) 52.4 (5.2) 52.0 (5.4) 52.0 (5.4) 0.2 1.4 No (%) current smokers 214 (65) 136 (41) 70 (21) 11.4 10.6*** No (%) >2 drinks alcohol/day 81 (24) 77 (23) 70 (21) 0.7 0.6 Physical measurements Body mass index (kg/m2) 25.5 (3.4) 25.3 (3.4) 25.2 (3.1) 1.0 1.9 Height (cm) 172 (6) 173 (7) 173 (7) 1.8 1.7 Weight (kg) 76 (11) 76 (12) 76 (11) 0.0 0.7 Systolic blood pressure (mmHg) 147 (21) 147 (22) 146 (20) 0.5 0.3 Diastolic blood pressure (mmHg) 81 (13) 83 (13) 83 (13) 2.6 1.5 Forced expiratory volume (l) 311 (77) 327 (77) 342 (73) 5.1 2.6* Plasma acute phase reactants Log10 C reactive protein (mg/l) 0.34 (0.50) 0.15 (0.50) 0.04 (0.50) 10.7 7.6*** Log10 serum amyloid A protein (mg/l) 0.89 (0.32) 0.84 (0.26) 0.78 (0.29) 6.1 4.9*** Albumin (g/l) 44.5 (2.5) 44.4 (2.6) 44.9 (2.2) 1.3 1.1 Other blood analytes No (%) H pylori seropositive 254 (77) 250 (76) 210 (64) 2.9 1.3 C pneumoniae titre (FC×106) 187 (61) 184 (57) 172 (60) 2.9 3.2* Total cholesterol (mmol/l) 6.29 (1.01) 6.20 (0.99) 6.13 (0.96) 1.4 1.6 HDL cholesterol (mmol/l) 1.13 (0.27) 1.14 (0.32) 1.19 (0.27) 2.6 2.1 Triglyceride (mmol/l) 2.05 (1.32) 2.00 (1.18) 1.74 (0.96) 3.1 1.8 Homocysteine (µmol/l) 15 (10) 15 (9) 14 (7) 0.2 0.7 Packed cell volume (%) 45.0 (3.3) 44.2 (3.1) 43.2 (3.0) 8.3 5.5*** Glucose (mmol/l) 5.6 (1.7) 5.6 (1.2) 5.6 (1.1) 0.9 0.6 Urea (mmol/l) 5.3 (1.4) 5.5 (1.4) 5.5 (1.3) 1.3 0.5 Urate (mmol/l) 349 (68) 355 (66) 350 (66) 0.0 0.4 Creatinine (µmol/l) 97 (13) 100 (13) 99 (14) 0.8 0.1 Insulin (mU/l) 16 (16) 18 (20) 15 (15) 0.7 0.6 †Derived from regression of the leucocyte count C on each characteristic separately adjusting for age and town only.
‡Derived from regression of the leucocyte count adjusting for age, town, smoking, body mass index, and markers of socioeconomic status (including height).
*P<0.01,**P<0.001,***P<0.0001.
Table D Comparisons of levels of risk factors and other characteristics in controls by thirds of albumin concentrations. Values are mean (SD) unless stated otherwise
Top (>46 g/l)
Middle (44-46 g/l)
Bottom (<6.4 g/l)
t value† t value‡ No of men 348 347 327 Age (years) 51.2 (5.4) 52.3 (5.3) 53.0 (5.3) 6.0 4.1*** No (%) current smokers 120 (34) 131 (38) 183 (56) 5.0 4.3*** No (%) >2 drinks alcohol/day 89 (26) 75 (22) 67 (21) 1.6 1.9 Physical measurements Body mass index (kg/m2) 25.6 (3.2) 25.5 (3.0) 24.9 (3.7) 3.3 1.1 Height (cm) 173 (7) 173 (7) 173 (6) 0.6 0.7 Weight (kg) 77 (11) 76 (10) 74 (13) 3.1 0.6 Systolic blood pressure (mmHg) 149 (21) 148 (21) 143 (21) 6.7 5.3*** Diastolic blood pressure (mmHg) 84 (13) 83 (13) 80 (13) 5.8 3.9*** Forced expiratory volume (l) 337 (74) 329 (74) 311 (79) 3.9 2.5 Plasma acute phase reactants Log10 C reactive protein (mg/l) 0.06 (0.48) 0.11 (0.50) 0.30 (0.58) 5.9 3.4** Log10 serum amyloid A protein (mg/l) 0.81 (0.26) 0.82 (0.26) 0.90 (0.36) 4.5 1.8 Albumin (g/l) 7.1 (1.7) 7.1 (1.9) 7.4 (1.7) 1.3 1.1 Other blood analytes No (%) H pylori seropositive 225 (65) 249 (72) 262 (80) 3.1 1.4 C pneumoniae titre (FC×106) 176 (60) 184 (60) 184 (60) 0.9 1.1 Total cholesterol (mmol/l) 6.47 (0.96) 6.20 (0.97) 5.90 (0.97) 8.9 6.9*** HDL cholesterol (mmol/l) 1.18 (0.27) 1.16 (0.32) 1.12 (0.27) 4.3 3.2* Triglyceride (mmol/l) 2.18 (1.39) 1.87 (1.10) 1.75 (0.95) 3.6 2.5 Homocysteine (µmol/l) 14 (8) 16 (11) 15 (8) 1.1 0.6 Packed cell volume (%) 44.3 (5.5) 42.7 (8.4) 41.0 (11) 4.8 4.5*** Glucose (mmol/l) 5.7 (1.6) 5.6 (1.1) 5.6 (1.4) 0.9 0.9 Urea (mmol/l) 5.2 (1.4) 5.5 (1.4) 5.2 (1.3) 3.7 2.7* Urate (mmol/l) 358 (68) 351 (71) 344 (61) 4.5 2.8* Creatinine (µmol/l) 100 (14) 99 (13) 97 (14) 2.6 0.5 Insulin (mU/l) 17 (18) 16 (16) 16 (17) 1.2 1.8 †Derived from regression of albumin values on each characteristic separately adjusting for age and town only.
‡Derived from regression of albumin values adjusting for age, town, smoking, body mass index, and markers of socioeconomic status (including height).
*P<0.01,**P<0.001,***P<0.0001.
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