corrected Table 3, full version

Intended for healthcare professionals

Corrected Table 3, full version

Table 3. Comparison of number needed to be invited to screening and screening costs (ages 16-54 years) for different strategies using clinical and genetic confirmation of the diagnosis

	No needed to screen to find one case	Screening cost per person invited for all stages	Screening cost per case detected	Life years gained (discounted at 1%)	Incremental drug costs	Incremental CHD event costs
Clinical confirmation
Universal (16 year olds)	1365	£7.15	£9754	5.2	£4818	-£200
Universal	1146	£8.42	£9645	3.5	£3704	-£171
Opportunistic (GP)^*	938	£9.67	£9072	3.7	£3707	-£171
Opportunistic (MI)	22	£13.15	£284	0.8	£2599	-£52
Family tracing	2.6	£51.16	£133	3.5	£3704	-£171
Genetic confirmation
Universal (16 year olds)	2729	£26.43	£72 140	5.2	£4818	-£200
Universal	2292	£31.38	£71 922	3.5	£3704	-£171
Opportunistic (GP)^*	1876	£37.72	£70 776	3.7	£3707	-£171
Opportunistic (MI)	43	£86.16	£3720	0.8	£2599	-£52
Family tracing (relatives, including cost of finding mutation in proband)	2.6	£719.26	£1873^§	3.5	£3704	-£171

CHD=coronary heart disease.
^* Patients attending general practitioner.
Patients hospitalised for myocardial infarction.
Genetic testing of family members only if mutation is identified in proband.
^§ Including cost of testing proband.