Jump to: Page Content, Site Navigation, Site Search,
You are seeing this message because your web browser does not support basic web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.
Albert F Schilte a Department of General
Practice, University of Maastricht, PO Box 616, 6200 MD Maastricht,
Netherlands, b Institute for Research
in Extramural Medicine, Vrije Universiteit, Amsterdam, Netherlands, c Department of Medical Sociology, University of
Maastricht
Correspondence to: A F Schilte Bert.Schilte{at}hag.unimaas.nl
| |
Abstract |
|---|
|
|
|---|
Objective:
To test whether a disclosure intervention improves subjective health and reduces medical consumption and sick
leave in somatising patients in general practice.
Design:
Non-blind randomised controlled trial.
Setting:
10 general practices in the Netherlands.
Participants:
161 patients who frequently attended
general practice with somatising symptoms.
Intervention:
Patients in the intervention group were
visited two to three times and invited to disclose emotionally
important events in their life. Control patients received normal care
from their general practitioners.
Main outcome measures:
Use of medical services (drugs
and healthcare visits), subjective health, and sick leave assessed by
self completion questionnaires after 6, 12, and 24 months.
Results:
Of the 161 patients, 137 completed the trial (85%). Both groups were comparable at baseline. The intervention had
no effect on the main outcome measures at any point. Intervention patients made one more visit to health care (95% confidence interval
4 to 6); the use of medicines did not change in both groups (
1 to
1); subjective health improved 3.6 points more in the control group
(
11.2 to 4.3); and disclosure patients were on sick leave one more
week (
1 to 3). Patients often had a depression or anxiety disorder
for which they were not receiving adequate care.
Conclusion:
Although the intervention was well
received by patients and doctors, disclosure had no effect on the
health of somatising patients in general practice.
|
What is already known on this topic
What this study adds
|
| |
Introduction |
|---|
|
|
|---|
Patients presenting with functional complaints are common in general practice. 1 2 Many patients present functional complaints only incidentally, whereas others have long term tendencies to seek medical attention for unexplained symptoms, often in relation to psychological stress, depression, or anxiety. 3 4 A few patients are seriously disabled through a long history of many unexplained symptoms, defined as somatisation disorder. 1 5 We adopted Lipowski's definition of somatisation: "A tendency to experience and express somatic distress and symptoms unaccounted for by pathological findings, to attribute them to physical illness, and to seek medical help for them. It is often assumed that somatisation becomes manifest in response to psychosocial stress brought about by life events that are personally stressful to the individual."3
A purely medical approach is clearly insufficient when patients present with somatisation. Psychological methods are needed that are both feasible and acceptable to patients. Traumatic experiences in childhood can lead to later somatisation,6-8 and doctors often ask about life events and stressful circumstances when seeking a psychosocial explanation for unexplained symptoms.
For most patients sharing emotions with someone is acceptable, and self disclosure is culturally embedded.9 Use of emotional expression techniques, or disclosure, has been shown to improve subjective health, stress related immune measures, and physical symptoms in healthy people and to reduce the number of visits to general practitioners.10-12 However, the effectiveness of disclosure in somatisation has not been evaluated in a randomised controlled trial.
We developed an intervention focusing on disclosure of traumatic
experiences for patients with somatisation in primary care. We studied
the effect of adding the disclosure intervention to regular care on use
of medical services, subjective health, and sick leave. In addition, we
studied the effect on quality of life, severity of symptoms, patient's
perception of support, and doctor's judgment of somatisation.
| |
Participants and methods |
|---|
|
|
|---|
We conducted a randomised controlled trial in 10 general practices cooperating in the Registration Network of General Practices around Maastricht in the Netherlands.13 We compared usual care with usual care plus the disclosure intervention. Randomisation was performed at the level of individual patients. Another nine randomly selected practices (five in Maastricht, and four in a sister project in Amsterdam) served as an extra control group to test for contamination of the effect of the trial as a whole; no intervention was introduced in these practices. The protocol was approved by the ethics committee of the Academic Hospital, Maastricht, and the University of Maastricht.
Recruitment of patients
We sent a postal questionnaire inquiring about somatisation
symptoms to patients aged 20-45 years who frequently attended general
practice. Frequent attendance was defined as 15 contacts or more with
the doctor, on the patient's initiative, in the past three years.
Routine examinations on the initiative of the doctor
for example, for
cervical smears or checking blood pressure
were not counted. We
estimated that this would select the 10% most frequently attending
patients in this age group.14 The somatisation
questionnaire, which we developed and validated in a pilot study,
contained the 37 somatisation symptoms listed in the Diagnostic
and Statistical Manual of Mental Disorders, third edition, revised
(DSM-III-R), with the relevant follow up questions.5 Symptoms counted when not explained by organic disease and use of medicines, alcohol, or drugs (based on the physical
examination of physicians, as reported by the patient in the
questionnaire). Frequently attending patients with five or more
somatisation symptoms were eligible for the
study.
1 2 15 16
Treatment conditions
Control patients were treated by their doctor in the usual
way. Intervention patients received, in addition to usual care, the
disclosure intervention. This consisted of two meetings with a trained
"disclosure doctor" at the patient's home. When important
information was disclosed, and if the patient agreed, a joint
consultation including the patient's doctor was planned as well. The
first meeting had to be within two weeks after inclusion in the trial
and lasted two hours; the second meeting, one week later, took one
hour; and the optional joint consultation, another week later, took 30 minutes to one hour.
Randomisation
Eligible patients received information on the trial and
were randomised when they agreed to participate. The randomisation was
stratified (one stratum per practice) by using a sequence of labelled
cards in opaque, sealed, numbered envelopes. An independent person
produced the randomisation envelopes, and the research assistant
(MBFL), who did not apply the intervention, executed the randomisation
procedure. Although the general practitioners knew which patients
received the intervention, they were not told which patients
participated as controls. The allocation scheme was broken after the
two year follow up.
Outcome measures
At baseline, six months, one year, and two years after
entry in the trial, patients completed a questionnaire on the outcome
measures. We calculated use of medical services (over the preceding six
months) from the total number of visits to the general practitioner and
other healthcare workers and the number of different drugs taken daily
for at least a week. Subjective health in the previous month (0=very
bad, 100=excellent) was operationalised as the average of a direct
question on health and a combined score of six questions on the
influence of symptoms on work, sleep, sports activities, social life,
mood, and ruminating about being ill. Sick leave (inability to work or
do household chores) was expressed in number of weeks over the
preceding six months.
Statistical analysis
We calculated the sample size required to detect a
difference of at least 25% (a worthwhile difference for a time
intensive treatment) between the intervention and control condition in
use of medical services. With a two sided significance of 5%, a power
of 80%, and taking into account a dropout rate of up to 25%, we
needed 80 patients per group. The analysis was based on intention to
treat and included all patients who completed baseline and 24 month
follow up questionnaires. We obtained missing data in returned
questionnaires by telephone contact with the patient. The relative
effectiveness of the intervention was determined by comparing the
change in primary outcome variables between baseline and two years
(Hodges-Lehman estimate of shift of the difference between intervention
and control groups in change of outcome variables, based on a two
sided Mann-Whitney U test with 95% confidence interval).
| |
Results |
|---|
|
|
|---|
The figure shows the progress of patients through the study. Of the 10 161 patients aged 20-45 years in the 10 practices, 1064 patients (10.5%) were frequent attenders without serious disease. The somatisation questionnaire was returned by 714 frequent attenders (67%), of whom 362 (51%) reported five or more somatisation symptoms. Non-respondents (350) were more likely to be unmarried men, living alone, and have psychological problems, particularly addiction to alcohol and hard drugs. Of the 362 patients eligible for the trial, 87 did not answer telephone calls or letters, and 35 declined to participate. We did not contact 79 patients because enough patients had already been enrolled. Accordingly, 161 patients were included in the trial.
|
|
Altogether 137 patients completed the trial; 24 patients (15%) dropped out and were not included in the final analyses. Ten patients (five in each group) did not return the baseline questionnaire, and 14 (six in the intervention group and eight in the control group) did not complete the two year follow up. Of these 14, two control patients were admitted to a psychiatric clinic, two died (one control, one intervention), three patients moved with no forwarding address (one intervention, two control), and the remaining seven did not return the two year questionnaire despite several reminders (four intervention, three control).
Of the 81 intervention patients, 77 received the disclosure intervention and completed the two meetings with the disclosure doctor; the remaining four dropped out before receiving the intervention. Twenty two patients participated in an additional joint consultation with their own doctor. Of the remaining 55 patients, 30 did not disclose important information in the two meetings, nine had previously discussed the disclosed information with their doctor, 11 did not want to share the disclosed information with their doctor, and five gave no clear reason why they did not want to participate in the joint consultation.
According to the patients and disclosure doctors, 47 patients disclosed
emotionally important information during the intervention. Topics of
disclosure were childhood abuse (sexual, physical, or mental), alcohol
dependency of parents, and loss of a parent or sibling at young age.
Quite often patients reported that they had borne onerous household
responsibilities as young children. A range of problems in adulthood
was disclosed, including physical or sexual abuse, alcoholism, problems
in relationships or at work, and social isolation. Patients commonly
disclosed combinations of problems
for example, sexual abuse in
childhood and depression in later life with marital problems. According
to the DSM-IV screening, 34 of the 77 patients had an active depressive
or anxiety disorder (16 a depressive disorder, 30 an anxiety disorder).
Two patients fulfilled the criteria for hypochondriasis and 18 for the
chronic benign pain syndrome.
At the start of the study, both groups had similar demographic and clinical characteristics (table 1). Changes in main outcome measures during two years of follow up were not significantly different between the two groups (table 2). Visits to health care increased by one more visit in the disclosure group at 24 months; the use of medicines did not change in either group; subjective health improved 3.6 points more in the control group; and disclosure patients were on sick leave one more week.
|
Detailed analyses of visits to specific healthcare professionals and use of different kinds of drugs showed no significant differences (table 3). In addition, changes in subsidiary outcome measures (quality of life, symptom check list-90, social support, and doctor's judgment of somatisation) did not differ between the groups (table 2). The general pattern was the same at the six and 12 month follow ups (data not shown). We found no significant differences in the subgroup analyses. Neither successful disclosure nor participation in the joint consultation affected the results.
|
In general, the disclosure intervention was well received: 57 out of 77 patients judged it positive, and at two years of follow up more intervention than control patients thought participation in the study had changed their health favourably (mean score 51 in intervention patients versus 47 in control patients (scale 0-100), P=0.11). However, at six and 12 months there was no difference between the groups on this measure. One patient criticised the disclosure intervention; she refused to be confronted with her childhood story again.
We did two checks for possible contamination between the two branches
of the trial. General practitioners were asked to identify the control
patients in their practice from a larger list towards the end of the
trial. Fourteen patients (17%) were correctly identified, 21 patients
(26%) were falsely identified as intervention patients, and 45 were
incorrectly thought to be non-participants (
=0.08). As a second
check, we followed 98 patients in nine practices in which no
intervention was introduced (data not presented). These 98 patients
showed similar characteristics at baseline to the intervention and
control patients, and changes on primary outcome measures at the two
year follow up were not significantly different from the intervention
and control group. The only difference was that patients in the
intervention group were judged by their doctors to somatise less than
patients in the external practices at the two year follow up (median
score 3 in intervention patients v 3.5 in control patients
(scale 1-5), P=0.01).
| |
Discussion |
|---|
|
|
|---|
The disclosure intervention had no effect on use of medical services, subjective health, or sick leave in somatising patients in general practice. We found no effect in patients who disclosed important information or in subgroups of patients with strong somatisation tendencies, depression, anxiety, or a traumatic childhood. However, a positive effect of disclosure in somatisation cannot be completely ruled out because the 95% confidence intervals were wide.
Design of intervention and study
The technique, duration, and frequency of our intervention
were in accordance with the recommendations in a recent meta-analysis
on emotional expression.10 The review found that short
writing tasks may improve subjective health and have a smaller effect
on health behaviours,10 although this last finding has
been disputed.11
Explanation for findings
The effect of emotional expression in long term somatising
patients may differ from that in student populations or other groups of
patients, such as holocaust survivors.
10 12
Somatising
patients have an established pattern of medical consumption, which may
be hard to alter with a short disclosure intervention. Their symptoms
may be independent of earlier life experiences. A more sustained
disclosure intervention, allowing patients to link symptoms to earlier
traumatic events and process this trauma, might give better results.
Other studies
We compared our findings with those of studies using other
techniques in somatisation. Management strategies focused on
structuring general practitioner or specialist care through psychiatric
consultations show positive20 as well as neutral21 results. Strategies aimed at "medical
behaviour" and illness attributions of patients in primary and
secondary care have been partially effective.
22 23
Strategies focusing on the other elements of Lipowski's definition of
somatisation,3 such as illness attributions and use of
health care, may give better results than disclosure of traumatic
experiences. Personal interest of doctors in their patients' life
stories remains crucial to communication24-26 but will
probably not in itself reduce use of medical services or sick leave or
improve subjective health.
| |
Acknowledgments |
|---|
We thank the patients and their general practitioners for participating, Frenk Peeters for advice on psychiatry, and Hubert Schouten and Arnold Kester for statistical advice. We also thank members of the European General Practice Work Group for their constructive advice.
Contributors: AFS ran the study, improved the design, acted as disclosure general practitioner, collected data, performed all data analyses, and was the main writer of the paper. PJMP had the original idea of the study, was involved in the design of the study in all phases, participated as disclosure general practitioner, helped with data analysis and interpretation, and participated in writing the paper. AHB was involved in the original idea and design of the study and closely cooperated with AFS in selecting and developing the measures of outcome, in collection, analysis, and interpretation of data, and in writing the paper. HEvdH was involved in the interpretation of data and writing the paper. MBFL collected data, was involved in improving the outcome measures, ran the randomisation procedure, and revised the paper. JThMvE was involved in the initial idea phase of the study and revised the paper. JAK was involved in the idea phase and design of the study, helped in the analysis and interpretation of data, and made many useful suggestions. Petra van den Berg acted as a disclosure doctor. JAK and PJMP act as guarantors.
| |
Footnotes |
|---|
Funding: Netherlands Organisation for Scientific Research and Council for Medical and Health Research (grant No 940-33-016).
Competing interests: None declared.
| |
References |
|---|
|
|
|---|
| 1. | Escobar JI, Rubio-Stipec M, Canino G, Karno M. Somatic symptom index (SSI): a new and abridged somatization construct. Prevalence and epidemiological correlates in two large community samples. J Nerv Ment Dis 1989; 177: 140-146[CrossRef][Medline]. |
| 2. | Portegijs PJM, van der Horst FG, Proot IM, Kraan HF, Gunther NC, Knottnerus JA. Somatization in frequent attenders of general practice. Soc Psychiatry Psychiatr Epidemiol 1996; 31: 29-37[Medline]. |
| 3. |
Lipowski ZJ.
Somatization: the concept and its clinical application.
Am J Psychiatry
1988;
145:
1358-1368 |
| 4. | Goldberg D, Bridges K. Somatic presentations of psychiatric illness in primary care setting. J Psychosom Res 1988; 32: 137-144[CrossRef][Medline]. |
| 5. | American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 3rd edition, revised. Washington, DC: APA, 1987:261-264. |
| 6. | Arnold RP, Rogers D, Cook DA. Medical problems of adults who were sexually abused in childhood. BMJ 1990; 300: 705-708. |
| 7. |
Portegijs PJM, Jeuken FM, van der Horst FG, Kraan HF, Knottnerus JA.
A troubled youth: relations with somatization, depression and anxiety in adulthood.
Fam Pract
1996;
13:
1-11 |
| 8. |
Craig TK, Boardman AP, Mills K, Daly Jones O, Drake H.
The south London somatisation study. I: Longitudinal course and the influence of early life experiences.
Br J Psychiatry
1993;
163:
579-588 |
| 9. | George E. A cultural and historical perspective on confession. In: Pennebaker JW, ed. Emotions, disclosure, and health. Washington, DC: American Psychological Association, 1995:11-22. |
| 10. | Smyth JM. Written emotional expression: effect sizes, outcome types, and moderating variables. J Cons Clin Psychol 1998; 66: 174-184[CrossRef][Medline]. |
| 11. | Pennebaker JW. Writing about emotional experiences as a therapeutic process. Psychol Sci 1997; 8: 162-166[CrossRef]. |
| 12. |
Pennebaker JW, Barger SD, Tiebout J.
Disclosure of traumas and health among Holocaust survivors.
Psychosom Med
1989;
51:
577-589 |
| 13. | Metsemakers JFM, Höppener P, Knottnerus JA, Kocken RJJ, Limonard CBG. Computerized health information in the Netherlands: a registration network of family practices. Br J Gen Pract 1992; 42: 102-106[Medline]. |
| 14. | De Bakker D, Kulu-Glasgow I, Abrahamse H. Annual report of Information Network for General Practitioners 1997 [in Dutch]. Utrecht: Dutch Institute for Primary Care Research, 1998. |
| 15. | Escobar JI, Waitzkin H, Silver RC, Gara M, Holman A. Abridged somatization: a study in primary care. Psychosom Med 1998; 60: 466-472[Abstract]. |
| 16. | Schilte AF, Portegijs PJM, Blankenstein AH, Knottnerus JA. Somatisation in primary care: clinical judgement and standardised measurement compared. Soc Psychiatry Psychiatr Epidemiol 2000; 35: 276-282[CrossRef][Medline]. |
| 17. | De Vries MW, ed. The experience of psychopathology: investigating mental disorders in their natural settings. Cambridge: Cambridge University Press, 1992. |
| 18. | Derogatis L, Cleary P. Confirmation of the dimensional structure of the SCL-90: a study in construct validation. J Clin Psychol 1977; 33: 981-989[CrossRef]. |
| 19. | Portegijs PJM. Somatization in frequent attenders of general practice [PhD thesis]. In: Maastricht: University of Maastricht, 1996. |
| 20. |
Smith GR, Rost K, Kashner TM.
A trial of the effect of a standardized psychiatric consultation on health outcomes and costs in somatizing patients.
Arch Gen Psychiatry
1995;
52:
238-243 |
| 21. | Katon WJ, Von Korff M, Lin E, Bush T, Russo J, Lipscomb P, et al. A randomized trial of psychiatric consultation with distressed high utilizers. Gen Hosp Psychiatry 1992; 14: 86-98[CrossRef][Medline]. |
| 22. |
Speckens AE, van Hemert AM, Spinhoven P, Hawton KE, Bolk JH, Rooijmans HG.
Cognitive behavioural therapy for medically unexplained physical symptoms: a randomised controlled trial.
BMJ
1995;
311:
1328-1332 |
| 23. | Morriss RK, Gask L, Ronalds C, Downes Grainger E, Thompson H, Goldberg D. Clinical and patient satisfaction outcomes of a new treatment for somatized mental disorder taught to general practitioners. Br J Gen Pract 1999; 49: 263-267[Medline]. |
| 24. |
Salmon P, Peters S, Stanley I.
Patients' perception of medical explanations for somatisation disorders: qualitative analysis.
BMJ
1999;
318:
372-376 |
| 25. | Cape J, McCulloch Y. Patients' reasons for not presenting emotional problems in general practice consultations. Br J Gen Pract 1999; 49: 875-879[Medline]. |
| 26. | Di Blasi Z, Harkness E, Ernst E, Georgiou A, Kleijnen J. Influence of context effects on health outcomes: a systematic review. Lancet 2001; 357: 757-762[CrossRef][Medline]. |
(Accepted 14 May 2001)
Read all Rapid Responses