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Predictors of normotension on withdrawal of antihypertensive drugs in elderly patients: prospective study in second Australian national blood pressure study cohort

BMJ 2002; 325 doi: https://doi.org/10.1136/bmj.325.7368.815 (Published 12 October 2002) Cite this as: BMJ 2002;325:815
  1. Mark R Nelson, NHMRC fellow (mark.nelson{at}med.monash.edu.au)a,
  2. Chris M Reid, directorb,
  3. Henry Krum, associate professora,
  4. Tui Muir, research nurseb,
  5. Philip Ryan, associate professorc,
  6. John J McNeil, heada
  1. aDepartment of Epidemiology and Preventive Medicine, Monash University, Alfred Hospital, Prahran 3181, Australia
  2. bCardiovascular Disease Prevention Unit, Baker Heart Research Institute, Alfred Hospital
  3. cDepartment of Public Health, Faculty of Health Sciences, University of Adelaide, Adelaide 5005, Australia
  1. Correspondence to: M R Nelson
  • Accepted 16 July 2002

Abstract

Objectives: To identify simple long term predictors of maintenance of normotension after withdrawal of antihypertensive drugs in elderly patients in general practice.

Design: Prospective cohort study.

Setting: 169 general practices in Victoria, Australia.

Participants: 503 patients aged 65-84 with treated hypertension who were withdrawn from all antihypertensive drugs and remained drug free and normotensive for an initial two week period; all were followed for a further 12 months.

Main outcome measures: Relative likelihood of maintaining normotension 12 months after drug withdrawal; relative likelihood of early return to hypertension after drug withdrawal.

Results: The likelihood of remaining normotensive at 12 months was greater among younger patients (65-74 years), patients with lower “on-treatment” systolic blood pressure, patients on single agent treatment, and patients with a greater waist:hip ratio. The likelihood of return to hypertension was greatest for patients with higher “on-treatment” systolic blood pressure.

Conclusions: Age, blood pressure control, and the number of antihypertensive drugs are important factors in the clinical decision to withdraw drug treatment. Because of consistent rates of return to antihypertensive treatment, all patients from whom such treatment is withdrawn should be monitored indefinitely to detect a recurrence of hypertension.

Footnotes

  • Funding Grant from the Victorian Health Promotion Foundation, a Victorian state government independent authority.

  • Conflict of interest JJMcN has held other research grants from Vichealth

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