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Association between psychological symptoms in adults and growth in early life: longitudinal follow up study

BMJ 2002; 325 doi: https://doi.org/10.1136/bmj.325.7367.749 (Published 05 October 2002) Cite this as: BMJ 2002;325:749
  1. Y B Cheung, biostatistician (ctecyb{at}nccs.com.sg)a,
  2. K S Khoo, headb,
  3. J Karlberg, directorc,
  4. D Machin, professord
  1. aDivision of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore 169610
  2. bDepartment of Medical Oncology, National Cancer Centre, Singapore
  3. cClinical Trials Centre, University of Hong Kong, Hong Kong, China
  4. dClinical Trials Research Unit, University of Sheffield, Sheffield S5 7AU
  1. Correspondence to: Y B Cheung
  • Accepted 20 June 2002

Abstract

Objectives: To test the hypothesis that birth weight for gestational age and weight gain in early childhood have a long term association with psychological distress in adults.

Design: Longitudinal study of 1958 birth cohort followed to age 42 years.

Setting: Population based birth cohort study.

Participants: 9731 cohort members with valid perinatal, postnatal, and adult data.

Main outcome measures: Malaise inventory scores measured at ages 23, 33, and 42 years. Generalised estimating equations approach used to analyse repeated measures.

Results: Psychological distress score was inversely related to birthweight z score and weight gain from birth to the age of 7 years. A unit increase in birthweight z score or childhood weight gain was associated with a mean reduction in psychological distress score of 0.10 (95% confidence interval 0.05 to 0.15) and 0.06 (0.02 to 0.10), respectively. Birth weight and weight gain were also inversely related to the odds of having a high level of psychological distress, with odds ratios being 0.90 (0.85 to 0.95) and 0.93 (0.89 to 0.98), respectively.

Conclusions: Psychological health in adults is related to fetal growth and growth in early childhood.

Footnotes

  • Funding YBC and DM were supported by the National Medical Research Council of Singapore

  • Competing interests None declared

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