Relation of childhood gastrointestinal disorders to autism: nested case-control study using data from the UK General Practice Research Database
BMJ 2002; 325 doi: https://doi.org/10.1136/bmj.325.7361.419 (Published 24 August 2002) Cite this as: BMJ 2002;325:419- Corri Black (cxb2{at}ph.abdn.ac.uk), research associate,
- James A Kaye, senior epidemiologist,
- Hershel Jick, associate professor of medicine.
- Correspondence to: C Black
- Accepted 20 June 2002
Abstract
Objectives: To assess whether children with autism are more likely to have a history of gastrointestinal disorders than children without autism.
Design: Nested case-control study.
Setting: UK General Practice Research Database.
Subjects: Children born after 1 January 1988 and registered with the General Practice Research Database within 6 months of birth.
Outcome measures: Chronic inflammation of the gastrointestinal tract, coeliac disease, food intolerance, and recurrent gastrointestinal symptoms recorded by the general practitioner.
Results: 9 of 96 (9%) children with a diagnosis of autism (cases) and 41 of 449 (9%) children without autism (matched controls) had a history of gastrointestinal disorders before the index date (the date of first recorded diagnosis of autism in the cases and the same date for controls). The estimated odds ratio for a history of gastrointestinal disorders among children with autism compared with children without autism was 1.0 (95% confidence interval 0.5 to 2.2).
Conclusions: No evidence was found that children with autism were more likely than children without autism to have had defined gastrointestinal disorders at any time before their diagnosis of autism.
Footnotes
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The Boston Collaborative Drug Surveillance Program is supported in part by grants from AstraZeneca, Berlex Laboratories, GlaxoSmithKline, Hoffmann-La Roche, Ingenix Pharmaceutical Services, Johnson & Johnson Pharmaceutical Research & Development, LLC, Pharmacia Corporation, and Novartis Farmacéutica. This study was not funded.
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Competing interests None declared.